Researchers at EvolutionaryScale have utilized an advanced AI model, ESM3, to design a novel green fluorescent protein named esmGFP. This protein’s genetic sequence is only 58% similar to its closest known counterpart, indicating a significant divergence that would have taken over 500 million years to evolve naturally. This breakthrough not only showcases the potential of AI in accelerating molecular design but also opens avenues for advancements in medical research and biotechnology.